Schistosomiasis Children Sensitized In Utero to Filariasis and Calmette-Guérin-Induced Immunity in Helminth- and Bacillus

Neonatal Immunity to Helminths and Mycobacterial Infection

Neonates exposed to parasite antigens (Ags) in utero may develop altered fetal immunity that could affect subsequent responses to infection. We hypothesized that cord blood lymphocytes (CBL) from offspring of mothers residing in an area highly endemic for schistosomiasis, filariasis, and tuberculosis in Kenya would either fail to respond or generate a predominantly Th2-associated cytokine respo...

B cell sensitization to helminthic infection develops in utero in humans.

Human neonates are generally deficient in their ability to generate humoral immunity. This deficiency is thought to reflect physiologic immaturity of T and B cell function and lack of previous exposure to exogenous Ags. To determine whether neonatal humoral immunity can be modified by maternal helminth infection during pregnancy, we assessed Ig production by cord blood lymphocytes from healthy ...

Relationship between NRAMP1 gene polymorphism and efficacy of BCG vaccine in a helminth-infected population.

Infection of mothers with schistosomiasis and filariasis has been shown to influence infant responses to neonatal Bacille Calmette-Guérin (BCG) immunization. The genetic makeup of infants is also considered an important determinant for the activity of BCG vaccine. The effect of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphism on the efficacy of BCG vaccine was exami...

Infection Promotes Virus Clearance and Protects from by Recombinant Bacillus Calmette-Guérin Syncytial Virus-Specific Th1 Cells Induced Efficient Lung Recruitment of Respiratory

Attempts to Achieve Millennium Development Goals in a Rural Area of Rio de Janeiro: Deworming and Control of Schistosomiasis

Introduction: According to the World Health Organization (WHO), helminth control could contribute to achieving 7 Millennium Development Goals (MDGs). The present study evaluated the impact of deworming on the infection rate of schistosomiasis in Sumidouro, Brazil and the consequences for the MDGs. Methods: The whole population of this area was invited to ...